Putative prion protein from Fugu (Takifugu rubripes).

  title={Putative prion protein from Fugu (Takifugu rubripes).},
  author={Barbara Christen and Kurt W{\"u}thrich and Simone Hornemann},
  journal={The FEBS journal},
  volume={275 2},
Prion proteins (PrP) of mammals, birds, reptiles and amphibians have been successfully cloned, expressed and purified in sufficient yields to enable 3D structure determination by NMR spectroscopy in solution. More recently, PrP ortholog genes have also been identified in several fish species, based on sequence relationships with tetrapod PrPs. Even though the sequence homology of fish PrPs to tetrapod PrPs is below 25%, structure prediction programs indicate a similar organization of the 3D… CONTINUE READING