Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay.

@article{Emerson2006PutativeNE,
  title={Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay.},
  author={Suzanne U. Emerson and Pilar Clemente-Casares and Nasser J Moiduddin and Vidya A Arankalle and Udana M Torian and Robert H. Purcell},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 3},
  pages={697-704}
}
Monolayers of Hep G2/C3A cells were inoculated with genotype 1 Hepatitis E virus (HEV) mixed with either anti-HEV or an appropriate control. After 5 or 6 days, cell monolayers were stained with anti-HEV and infected cells were identified by immunofluorescence microscopy and counted. Anti-HEV from vaccinated or infected rhesus monkeys neutralized the virus, as did mAbs that recognized epitopes on the C terminus of a recombinant vaccine protein. Antibodies were broadly cross-reactive, since… CONTINUE READING
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