Putative interhelical interactions within the PheP protein revealed by second-site suppressor analysis.

@article{Dogovski2003PutativeII,
  title={Putative interhelical interactions within the PheP protein revealed by second-site suppressor analysis.},
  author={Con Dogovski and J. I. Pi and Alexandre Pittard},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 21},
  pages={
          6225-32
        }
}
Highly conserved glycine residues within span I and span II of the phenylalanine and tyrosine transporter PheP were shown to be important for the function of the wild-type protein. Replacement by amino acids with increasing side chain volume led to progressive loss of transport activity. Second-site suppression studies performed with a number of the primary mutants revealed a tight packing arrangement between spans I and II that is important for function and an additional interaction between… CONTINUE READING

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