Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

@article{Velikova2016PutativeHK,
  title={Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens},
  author={N. Velikova and Simone Fulle and A. S. Manso and M. Mechkarska and P. Finn and J. Conlon and M. Oggioni and J. Wells and A. Marina},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
  • N. Velikova, Simone Fulle, +6 authors A. Marina
  • Published 2016
  • Biology, Medicine
  • Scientific Reports
  • Novel antibacterials are urgently needed to address the growing problem of bacterial resistance to conventional antibiotics. Two-component systems (TCS) are widely used by bacteria to regulate gene expression in response to various environmental stimuli and physiological stress and have been previously proposed as promising antibacterial targets. TCS consist of a sensor histidine kinase (HK) and an effector response regulator. The HK component contains a highly conserved ATP-binding site that… CONTINUE READING
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