Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

@article{Stratmann1997PutativeCO,
  title={Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.},
  author={Rembert Stratmann and Marion Krieg and Richard Weber Haas and Karl Heinz Plate},
  journal={Journal of neuropathology and experimental neurology},
  year={1997},
  volume={56 11},
  pages={1242-52}
}
The hypoxia-inducible endothelial cell-specific mitogen vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is expressed in low amounts in adult human brain, but is highly upregulated in the perinecrotic palisading cells of glioblastomas. We observed high VEGF expression in cerebellar hemangioblastomas, which are highly vascular, nonnecrotic and presumably nonhypoxic tumors, and hypothesized that a mechanism other than hypoxia leads to VEGF upregulation. Because… CONTINUE READING
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