Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5).

Abstract

OBJECTIVES It has been demonstrated that at nanomolar concentrations benzocaine increased, whereas at micromolar concentrations, it blocked hKv1.5 channels in a voltage-dependent manner and modified the voltage-dependence of channel activation. The present study was undertaken to localize the putative binding sites involved in the 'agonists' and blocking… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.