Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5).


OBJECTIVES It has been demonstrated that at nanomolar concentrations benzocaine increased, whereas at micromolar concentrations, it blocked hKv1.5 channels in a voltage-dependent manner and modified the voltage-dependence of channel activation. The present study was undertaken to localize the putative binding sites involved in the 'agonists' and blocking… (More)


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