Putative RNA capping activities encoded by brome mosaic virus: methylation and covalent binding of guanylate by replicase protein 1a.

@article{Ahola1999PutativeRC,
  title={Putative RNA capping activities encoded by brome mosaic virus: methylation and covalent binding of guanylate by replicase protein 1a.},
  author={Tero E. Ahola and Paul Ahlquist},
  journal={Journal of virology},
  year={1999},
  volume={73 12},
  pages={10061-9}
}
Brome mosaic virus (BMV) RNA replication is directed by two virus-encoded proteins, 1a and 2a. The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1, which has been implicated in capping viral RNAs. In this study, we examined the enzymatic activities of BMV 1a expressed in yeast, where the protein is fully functional in RNA replication. 1a methylated GTP, dGTP, and the cap analogs GpppG and GpppA, using S-adenosylmethionine (AdoMet) as the methyl donor… CONTINUE READING
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Cis-acting signals in bromovirus RNA replication and gene expression: networking with viral proteins and host factors

  • M. Sullivan, P. Ahlquist
  • Semin. Virol
  • 1997

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