Putative N‐terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cells

@article{Ishiura1989PutativeNS,
  title={Putative N‐terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cells},
  author={S. Ishiura and T. Tsukahara and T. Tabira and H. Sugita},
  journal={FEBS Letters},
  year={1989},
  volume={257}
}
The main characteristic changes observed in Alzheimer's disease (AD) are the presence of neurofibrillary tangles and the deposition of amyloid A4 peptides. The most abundant amyloid A4 peptide species in AD (which we tentatively named A4') is composed of 39 amino acids, which is devoid of the 3 N‐terminal amino acids, Asp‐Ala‐Glu, of the originally reported A4 peptide. We synthesized a model peptide substrate, Suc‐Ala‐Glu‐methylcoumarinamide (MCA), to identify the proteinase that splits the A4… Expand
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