Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

Abstract

Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can downregulate gene expression, possibly by blocking the transcriptional machinery. Here we have used a genome-wide bioinformatic approach to identify Putative G-Quadruplex… (More)
DOI: 10.1186/1471-2164-10-362

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