Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.

@article{Sakaguchi2006PutativeG,
  title={Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.},
  author={Takehisa Sakaguchi and Masazumi Nishimoto and Satoru Miyagi and Atsushi Iwama and Yohei Morita and Naoki Iwamori and Hiromitsu Nakauchi and Hiroshi Kiyonari and Masami Muramatsu and Akihiko Okuda},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 17},
  pages={6557-70}
}
Many genes have been identified that are specifically expressed in multiple types of stem cells in their undifferentiated state. It is generally assumed that at least some of these putative "stemness" genes are involved in maintaining properties that are common to all stem cells. We compared gene expression profiles between undifferentiated and differentiated embryonic stem cells (ESCs) using DNA microarrays. We identified several genes with much greater signal in undifferentiated ESCs than in… CONTINUE READING