Pustular psoriasis and related pustular skin diseases

@article{Bachelez2018PustularPA,
  title={Pustular psoriasis and related pustular skin diseases},
  author={Herv{\'e} Bachelez},
  journal={British Journal of Dermatology},
  year={2018},
  volume={178}
}
  • H. Bachelez
  • Published 1 March 2018
  • Medicine, Biology
  • British Journal of Dermatology
Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug‐induced acute exanthematous generalized pustular eruption. Identified mutations in IL36RN, CARD14… 
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38 Citations
Highly Influential Citations
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Background Citations
17
Methods Citations
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38 Citations

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Citation Type

Generalized Pustular Psoriasis: Divergence of Innate and Adaptive Immunity
TLDR
The novel anti-IL-36R antibodies are particularly promising and may revolutionize management of the disease.
Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options
TLDR
The clinical features of PPP and GPP are reviewed, and current understanding of the genetics and immunopathology of these conditions are reviewed; it also provides an update on emerging treatments.
Generalized Pustular Psoriasis: Clinical Management and Update on Autoinflammatory Aspects
TLDR
Challenges regarding the precise clinical diagnosis and evaluation of clinical symptoms in GPP are addressed, and the current understanding of molecular pathomechanisms behind GPP as an autoinflammatory keratinization disease is updated and summarized.
Update on the aetiology and mechanisms of generalized pustular psoriasis
TLDR
Generalized pustular psoriasis is a chronic disease characterized by non-bacterial pustules, and the mechanisms of pustule formation involve the LL37/TLR pathway, in which LL37 acts as an alarmin, interacting with TLR and activating the NF-κB and MAPK pathways.
Pustular Psoriasis: From Pathophysiology to Treatment
TLDR
Recent progresses in the identification of genetic mutations and immunological mechanisms have promoted a better understanding of PP pathogenesis and might have important consequences on diagnostic refinement and treatment.
Autoinflammatory diseases predominantly affecting the skin
Variants of CARD14 are predisposing factors for generalized pustular psoriasis (GPP) with psoriasis vulgaris but not for GPP alone in a Chinese population
  • L Li, J. You, F. Zhang
  • Medicine
    The British journal of dermatology
  • 2019
TLDR
GPP is traditionally classified as the most severe form of psoriasis, although some scholars have proposed that GPP alone can be treated as a distinct etiology because that this condition is strikingly different from PV in terms of its clinical, histological and genetic background.
Biologics in the treatment of pustular psoriasis
TLDR
This review focuses on the efficacy and safety of biologics, including anti-IL‐1β (gevokizumab and canakinumab), anti- IL‐1 R (anakinra), pro-IL-36 R (BI 655130), and anti-tumor necrosis factor-α (etanercept, infliximab, and adalimumab), for treating pustular psoriasis.
Treatment and Management of Psoriasis: A review
TLDR
This disease can significantly impact on a patient's quality of life and is connected comorbidities comprise psoriatic arthritis, obesity and the metabolic syndrome, diseases of cardiovascular system and liver with fats.
Successful therapy with secukinumab in a patient with generalized pustular psoriasis carrying homozygous IL36RN p.His32Arg mutation
TLDR
The efficiency of secukinumab, an IL-17 inhibitor, is described in a patient with GPP and carrying a homozygous IL36RN p.His32Arg mutation, previously described as a hypomorphic mutation with reduced IL-36Ra protein expression.
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TLDR
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TLDR
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TLDR
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