Pushing the performance limits of reversed-phase ultra high performance liquid chromatography with 1.3μm core-shell particles.

@article{Sanchez2013PushingTP,
  title={Pushing the performance limits of reversed-phase ultra high performance liquid chromatography with 1.3μm core-shell particles.},
  author={Arlyn C Sanchez and Gareth Friedlander and Szabolcs Fekete and Jason A Anspach and Dvy Guillarme and Mike Chitty and Tivadar Farkas},
  journal={Journal of chromatography. A},
  year={2013},
  volume={1311},
  pages={90-7}
}
Innovative columns made with very small core-shell particles (1.0-1.4μm) were investigated over a wide experimental space using state-of-the-art ultra high performance liquid chromatography (UHPLC) instruments. Among the columns tested is one that is now commercially available and is made with 1.3μm core-shell particles consisting of non-porous cores about 0.9μm in size and porous shells <0.2μm thick. This work demonstrated that exceptionally low observed minimum plate heights of 2.2μm could be… CONTINUE READING

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