Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity.

@article{Archer2017PushingTE,
  title={Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity.},
  author={N. Archer and Migena N Dilolli and L. Miller},
  journal={The Journal of investigative dermatology},
  year={2017},
  volume={137 11},
  pages={
          2257-2259
        }
}
Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role. 
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References

SHOWING 1-10 OF 10 REFERENCES
Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.
Epithelial antimicrobial defence of the skin and intestine
The skin microbiome
Microbial Symbiosis with the Innate Immune Defense System of the Skin
TNFAIP3 Gene Polymorphisms Are Associated with Response to TNF Blockade in Psoriasis