Purkinje cells in degenerative diseases of the cerebellum and its connections: a Golgi study.

@article{Ferrer1988PurkinjeCI,
  title={Purkinje cells in degenerative diseases of the cerebellum and its connections: a Golgi study.},
  author={Isidro Ferrer and J Kulisevski and J. M. Moreno Vazquez and Georgina Gonz{\'a}lez and Merc{\'e}des Pineda},
  journal={Clinical neuropathology},
  year={1988},
  volume={7 1},
  pages={22-8}
}
The cellular pathology of Purkinje cells in several degenerative diseases of the cerebellum and its connections was studied with the rapid Golgi method. Purkinje cells from a patient with Creutzfeldt-Jakob disease (case 1) showed decreased numbers of spiny branchlets. In a patient with a cystic infarct of the cerebellar white matter and chronic deafferentation of the cerebellar cortex (case 2) there was a striking increase in the density of spines on the primary dendrites. No abnormalities were… CONTINUE READING