Purkinje cell survival and axonal regeneration are age dependent: an in vitro study.

@article{Dusart1997PurkinjeCS,
  title={Purkinje cell survival and axonal regeneration are age dependent: an in vitro study.},
  author={Isabelle Dusart and Matti S Airaksinen and Constantino Sotelo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 10},
  pages={3710-26}
}
Purkinje cells are among the most resistant neurons to axotomy and the most refractory to axonal regeneration. By using organotypic cultures, we have studied age- and environment-related factors implicated in Purkinje cell survival and axonal regeneration. Most Purkinje cells taken from 1- to 5-d-old rats, the period in which these neurons are engaged in intense synaptogenesis and dendritic remodeling, die 1 week after plating, whereas if cultured before or after this period, Purkinje cells… CONTINUE READING
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