Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics.

@article{Baader1996PurkinjeCL,
  title={Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics.},
  author={Stephan L Baader and Margo L Schilling and Bernhard Rosengarten and Walter Pretsch and Harald F Teutsch and John Oberdick and Karl Schilling},
  journal={Developmental biology},
  year={1996},
  volume={174 2},
  pages={393-406}
}
We utilized a strain of mice, derived from a radiation mutagenesis experiment and carrying an activity-attenuated allele of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD), to analyze the development of the cell lineage leading to cerebellar Purkinje neurons. Due to random X inactivation during early embryonic development, X- linked genes can be used to distinguish between clonally related populations of cells in X inactivation mosaics. Following histochemical staining for G6PD… CONTINUE READING

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