Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg.

@article{Roegge2006PurkinjeCA,
  title={Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg.},
  author={Cindy S. Roegge and John R. Morris and Sherilyn Villareal and Victor C. Wang and Brian E. Powers and Anna Y. Klintsova and William T. Greenough and Isaac N Pessah and Susan L. Schantz},
  journal={Neurotoxicology and teratology},
  year={2006},
  volume={28 1},
  pages={
          74-85
        }
}
We recently reported that rats exposed to PCBs and MeHg during development were impaired on the rotating rod, a test of balance and coordination that is often indicative of cerebellar damage. In addition, developmental PCB exposure is known to dramatically reduce circulating thyroid hormone concentrations, which may have a negative impact on cerebellar development. Therefore, we investigated the effects of combined PCB and MeHg exposure on Purkinje cells and the cerebellum. The serum and brains… CONTINUE READING

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