Purkinje cell activity during motor learning

  title={Purkinje cell activity during motor learning},
  author={Peter F. C. Gilbert and William Thomas Thach},
  journal={Brain Research},

Responses of cerebellar Purkinje cells to slip of a hand-held object.

It appears that simple- and complex-spike to receptive fields are not always identical or even closely related, and the majority of Purkinje and unidentified neurons that responded to the perturbation had cutaneous receptive fields, although some had proprioceptive fields.

Cerebellar feedback signals of a passive hand movement in the awake monkey

From three intact and awake monkeys, 149 Purkinje cells and 44 presumed mossy fibres were recorded in the intermediate part of the cerebellar anterior lobe, and this activity was analyzed with regard

Purkinje cell spike firing in the posterolateral cerebellum: correlation with visual stimulus, oculomotor response, and error feedback.

It is concluded that posterolateral Pc CS and SS firing changes following an off-gaze visual target appearance in a preferred location when there is a subsequent saccade to that location.

Climbing Fibers Control Purkinje Cell Representations of Behavior

This study shows that CSs dynamically control the information encoded in a Purkinje cell's SS activity by rapidly increasing or decreasing the SS sensitivity to kinematics and/or performance errors independent of firing rate.

Modulation of Complex-Spike Duration and Probability during Cerebellar Motor Learning in Visually Guided Smooth-Pursuit Eye Movements of Monkeys

It is shown across multiple learning paradigms that both the probability and duration of CS responses are correlated with the magnitudes of neural and behavioral learning in awake behaving monkeys, and when the direction of the instruction for learning repeatedly was in the same direction or alternated directions, the duration and probability decreased over a learning block along with the magnitude of trial-over-trial neural learning.

Cerebellar unit responses of the mossy fibre system to passive movements in the decerebrate cat

Results indicate that static parameters of a passive limb movement are conveyed via the MF input to the cerebellar cortex through a type of position information encoding termed “indirect mode of transmission”.

Complex Spike Activity of Purkinje Cells in the Oculomotor Vermis during Behavioral Adaptation of Monkey Saccades

The data suggest that the CS activity of P-cells in the oculomotor vermis signals the direction but not the magnitude of eye-position error during saccade adaptation, consistent with cerebellar learning models that have been proposed to explain adaptation of the vestibulo-ocular reflex.

Changes in the responses of Purkinje cells in the floccular complex of monkeys after motor learning in smooth pursuit eye movements.

Current theories of cerebellar learning would have to be modified to account for simple- and complex-spike firing of floccular Purkinje cells reported here, largely consistent with previous evidence that image motion drives complex spikes with a direction selectivity opposite that for simple spikes.

Changes in Purkinje Cell Simple Spike Encoding of Reach Kinematics during Adaption to a Mechanical Perturbation

Extensive alterations were observed in individual Purkinje cell encoding of reach kinematics, although the movements were nearly identical in the baseline and adapted states, indicating that adaption to mechanical perturbation of a reaching movement is accompanied by widespread modifications in the simple spike encoding.



How the cerebellum could memorise movements

A new way by which the cerebellum could be used for storing information relating to movements, based on the postulate that the signals relating to motor output have been computed in the cerebral cortex and transmitted from there to the Cerebellum for storage.

A theory of cerebellar cortex

  • D. Marr
  • Biology, Psychology
    The Journal of physiology
  • 1969
1. A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills. Two forms of input—output relation are described, both consistent with

Servo Action in Human Voluntary Movement

Muscular movements are under the control of a servo similar in many ways to those used in engineering control systems but with a subtlety of design not found in man-made servo mechanisms—including an

How the Cerebellum may be Used

Recent anatomical information suggests new input–output relations for the cerebellum. These have interesting implications about the role of motor cortex in the learning and controlling of voluntary