PurityEst: estimating purity of human tumor samples using next-generation sequencing data

@article{Su2012PurityEstEP,
  title={PurityEst: estimating purity of human tumor samples using next-generation sequencing data},
  author={Xiaoping Su and Xiang Lin and Jianping Zhang and Funda Meric-Bernstam and John N. Weinstein},
  journal={Bioinformatics},
  year={2012},
  volume={28 17},
  pages={
          2265-6
        }
}
UNLABELLED We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared with DNA copy number-based estimation. AVAILABILITY PurityEst has been implemented in PERL and is available at… CONTINUE READING
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