Purinoceptor-coupled Cl- channels in mouse heart: a novel, alternative pathway for CFTR regulation.

@article{Duan1999PurinoceptorcoupledCC,
  title={Purinoceptor-coupled Cl- channels in mouse heart: a novel, alternative pathway for CFTR regulation.},
  author={Dayue Darrel Duan and Linda L Ye and Fiona Britton and Laurence J. Miller and Jun Yamazaki and Burton Horowitz and Joseph R. Hume},
  journal={The Journal of physiology},
  year={1999},
  volume={521 Pt 1},
  pages={43-56}
}
1. P2-purinoceptors couple extracellular ATP to the activation of a Cl- current (ICl,ATP) in heart. We studied the molecular mechanism and intracellular signalling pathways of ICl,ATP activation in mouse heart. 2. Extracellular adenosine-5'-O-(3-thiotriphosphate) (ATPgammaS; 100 microM) activated ICl,ATP in both atrial and ventricular myocytes. A specific PKC inhibitor, bisindolylmaleimide blocked the effect of ATPgammaS while a PKC activator, phorbol 12, 13-dibutyrate (PDBu) activated a… CONTINUE READING

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