Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines.

@article{Wolkoff1995PurinoceptorPI,
  title={Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines.},
  author={L I Wolkoff and Ron Perrone and Shelley A. Grubman and David W. Lee and Stephen P. Soltoff and Leann C Rogers and Martin Beinborn and Shaona L Fang and Seng H. Cheng and Douglas M. Jefferson},
  journal={Cell calcium},
  year={1995},
  volume={17 5},
  pages={
          375-83
        }
}
The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. Intracellular free calcium was measured in cell suspensions using the fluorescent probe Fura-2 and a fluorescence spectrophotometer. Halide efflux was measured in single cells using… CONTINUE READING

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