Purinethiols as feedback inhibitors of purine synthesis in ascites tumor cells.

@article{Lepage1961PurinethiolsAF,
  title={Purinethiols as feedback inhibitors of purine synthesis in ascites tumor cells.},
  author={G A Lepage and Mark Jones},
  journal={Cancer research},
  year={1961},
  volume={21},
  pages={642-9}
}
The capacity of several purinethiol derivatives to produce prolongation of survival in mice bearing ascites-cell tumors and to produce feedback inhibition of purine synthesis in vivo in the tumor cells was investigated. Included were tumors susceptible and tumors resistant to treatment with 6-thioguanine. With susceptible tumors, certain of the purinethiols could increase survival of tumor-bearing mice as the sole treatment; some produced synergistic responses in combination with azaserine, and… CONTINUE READING