Purines and neutrophil leukocytes.

@article{Fredholm1997PurinesAN,
  title={Purines and neutrophil leukocytes.},
  author={Bertil B. Fredholm},
  journal={General pharmacology},
  year={1997},
  volume={28 3},
  pages={
          345-50
        }
}
1. Adenosine is a normal constituent of all body fluids and its levels are raised, for example, by hypoxia and ischemia. In addition, both adenosine and ATP can be released by endothelial cells and neutrophils in response to physiologic stimulation. 2. Human neutrophil leukocytes possess multiple adenosine receptors and P2 purinoceptors. 3. ATP can increase intracellular Ca2+ levels in neutrophils, cause degranulation and enzyme release, potentiate the oxidative burst and enhance their adhesion… CONTINUE READING

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