Purines, purinergic receptors, and cancer.

  title={Purines, purinergic receptors, and cancer.},
  author={Francesco di Virgilio},
  journal={Cancer research},
  volume={72 21},
Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent modulators of immune cell responses and cytokine release, and (iii) key players in host-tumor interaction. Moreover, both ATP and adenosine directly… CONTINUE READING


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