Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death

@article{Lecca2012PurinergicTS,
  title={Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death},
  author={Davide Lecca and Stefania Ceruti and Marta Fumagalli and Maria P. Abbracchio},
  journal={Purinergic Signalling},
  year={2012},
  volume={8},
  pages={539-557}
}
In the last decades, the discovery that glial cells do not only fill in the empty space among neurons or furnish them with trophic support but are rather essential participants to the various activities of the central and peripheral nervous system has fostered the search for the signalling pathways controlling their functions. Since the early 1990s, purines were foreseen as some of the most promising candidate molecules. Originally just a hypothesis, this has become a certainty as experimental… CONTINUE READING
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