Purinergic stimulation of cell division and differentiation: mechanisms and pharmacological implications.

@article{Rathbone1992PurinergicSO,
  title={Purinergic stimulation of cell division and differentiation: mechanisms and pharmacological implications.},
  author={Michel Piers Rathbone and S Deforge and B A Deluca and Bruno Gabel and C Laurenssen and Pamela J. Middlemiss and Steve Parkinson},
  journal={Medical hypotheses},
  year={1992},
  volume={37 4},
  pages={213-9}
}
Extracellular purine nucleosides and nucleotides in micromolar concentrations stimulate proliferation of a variety of cell types in vitro and in vivo. As well they act synergistically with NGF to stimulate neurite outgrowth from PC12 cells. A variety of purine nucleosides and deoxyribonucleosides promote cell proliferation and increase intracellular cAMP… CONTINUE READING