Purinergic signalling in the gastrointestinal tract and related organs in health and disease

@article{Burnstock2013PurinergicSI,
  title={Purinergic signalling in the gastrointestinal tract and related organs in health and disease},
  author={Geoffrey Burnstock},
  journal={Purinergic Signalling},
  year={2013},
  volume={10},
  pages={3-50}
}
Purinergic signalling plays major roles in the physiology and pathophysiology of digestive organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive intestinal peptide, is a cotransmitter in non-adrenergic, non-cholinergic inhibitory neuromuscular transmission. P2X and P2Y receptors are widely expressed in myenteric and submucous enteric plexuses and participate in sympathetic transmission and neuromodulation involved in enteric reflex activities, as well as influencing… CONTINUE READING