Purinergic signaling underlies CFTR control of human airway epithelial cell volume.

@article{Braunstein2004PurinergicSU,
  title={Purinergic signaling underlies CFTR control of human airway epithelial cell volume.},
  author={Gavin M Braunstein and Akos Zsembery and Torry A. Tucker and Erik M. Schwiebert},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2004},
  volume={3 2},
  pages={99-117}
}
BACKGROUND Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function in cystic fibrosis (CF) causes dysregulation of multiple ion channels, water channels, and acid-base transporters in epithelia. As such, we hypothesized that dysregulation of many critical ion channels and transporters may cause defects in human airway epithelial cell volume regulation. METHODS Cell volume, regulatory volume decrease, and its regulation was assessed in real-time via Coulter Counter… CONTINUE READING

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