Purinergic signaling in the immune system.

  title={Purinergic signaling in the immune system.},
  author={Francesco Di Virgilio and Marta Vuerich},
  journal={Autonomic neuroscience : basic & clinical},
Extracellular ATP and its metabolite adenosine are increasingly recognized as key mediators of the immune response. Depending on the concentration, ATP may act as an immunostimulant or an immunodepressant, while adenosine is generally acknowledged to be a potent immunosupressor molecule. Signals delivered by extracellular ATP and adenosine are detected and transduced by P2 and P1 receptors, respectively. Virtually all immune cells express P2 and P1 receptors, thus purinergic signaling affects… CONTINUE READING
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