Purinergic signaling in retinal degeneration and regeneration.

  title={Purinergic signaling in retinal degeneration and regeneration.},
  author={Andreas Reichenbach and Andreas Bringmann},
Purinergic signaling is centrally involved in mediating the degeneration of the injured and diseased retina, the induction of retinal gliosis, and the protection of the retinal tissue from degeneration. Dysregulated calcium signaling triggered by overactivation of P2X7 receptors is a crucial step in the induction of neuronal and microvascular cell death under pathogenic conditions like ischemia-hypoxia, elevated intraocular pressure, and diabetes, respectively. Overactivation of P2X7 plays also… CONTINUE READING
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