Purinergic signaling in embryonic and stem cell development

  title={Purinergic signaling in embryonic and stem cell development},
  author={Geoffrey Burnstock and Henning Ulrich},
  journal={Cellular and Molecular Life Sciences},
Nucleotides are of crucial importance as carriers of energy in all organisms. However, the concept that in addition to their intracellular roles, nucleotides act as extracellular ligands specifically on receptors of the plasma membrane took longer to be accepted. Purinergic signaling exerted by purines and pyrimidines, principally ATP and adenosine, occurs throughout embryologic development in a wide variety of organisms, including amphibians, birds, and mammals. Cellular signaling, mediated by… CONTINUE READING
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