Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.

@article{Greig2003PurinergicRA,
  title={Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.},
  author={Aina V. H. Greig and Claire Linge and Giorgio Terenghi and D. Angus Mcgrouther and Geoffrey Burnstock},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={120 6},
  pages={
          1007-15
        }
}
We investigated the expression of P2X5, P2X7, P2Y1 and P2Y2 receptor subtypes in normal human epidermis and in relation to markers of proliferation (PCNA and Ki-67), keratinocyte differentiation (cytokeratin K10 and involucrin) and markers of apoptosis (TUNEL and anticaspase-3). Using immunohistochemistry, we showed that each of the four receptors was expressed in a spatially distinct zone of the epidermis, suggesting different functional roles for these receptors. Functional studies were… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Receptors for purines and pyrimidines.

  • Pharmacological reviews
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Expression of proliferating cell nuclear antigen/cyclin in human keratinocytes.

  • The Journal of investigative dermatology
  • 1989
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Quantification of cells cultured on 96-well plates.

  • Analytical biochemistry
  • 1989
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Purinergic receptors

BF King, G Burnstock
  • 2002
VIEW 1 EXCERPT

Purinergic signaling and vascular cell proliferation and death.

  • Arteriosclerosis, thrombosis, and vascular biology
  • 2002
VIEW 2 EXCERPTS

HO: Purinoceptor-mediated calcium mobilization and proliferation in HaCaT keratinocytes

WK Lee, SW Choi, +3 authors Kim
  • J Dermatol Sci 25:97^105,
  • 2001
VIEW 1 EXCERPT