Purinergic receptors and gastrointestinal secretomotor function

  title={Purinergic receptors and gastrointestinal secretomotor function},
  author={Fievos L Christofi},
  journal={Purinergic Signalling},
Secretomotor reflexes in the gastrointestinal (GI) tract are important in the lubrication and movement of digested products, absorption of nutrients, or the diarrhea that occurs in diseases to flush out unwanted microbes. Mechanical or chemical stimulation of mucosal sensory enterochromaffin (EC) cells triggers release of serotonin (5-HT) (among other mediators) and initiates local reflexes by activating intrinsic primary afferent neurons of the submucous plexus. Signals are conveyed to… CONTINUE READING
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