Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices.

@article{Kanekar2009PurinergicRA,
  title={Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices.},
  author={Shami L Kanekar and Cuihong Jia and Colleen Cosgrove Hegg},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 6},
  pages={1424-34}
}
One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, whether purinergics have a neurotrophic role in the olfactory neuroepithelium has not been investigated. Thus, we monitored the ATP-induced release of neuropeptide Y (NPY), a… CONTINUE READING
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