Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

  title={Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.},
  author={Nanhong Lou and Takahiro Takano and Yong Pei and Anna Lenice Xavier and Steven A Goldman and Maiken Nedergaard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 4},
Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood-brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-protein coupled, 12)-mediated chemotaxis of microglia processes is required for the rapid closure of the BBB. Mice treated with the P2RY12 inhibitor clopidogrel, as well as those in which P2RY12 was… CONTINUE READING
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