Purinergic neuromuscular transmission is absent in the colon of P2Y(1) knocked out mice.


Purinergic and nitrergic co-transmission is the dominant mechanism responsible for neural-mediated smooth muscle relaxation in the gastrointestinal tract. The aim of the present paper was to test whether or not P2Y(1) receptors are involved in purinergic neurotransmission using P2Y(1)(−/−) knock-out mice. Tension and microelectrode recordings were performed… (More)
DOI: 10.1113/jphysiol.2011.224345