Purinergic modulation in the development of the rat uncrossed retinotectal pathway.

  title={Purinergic modulation in the development of the rat uncrossed retinotectal pathway.},
  author={A L Tavares Gomes and Francisco Carlos Barbosa Maia and Priscilla Oliveira-Silva and A L Marques Ventura and Roberto Paes-de-Carvalho and Claudio Alberto Serfaty and Paula Campello-Costa},
  volume={163 4},
Adenosine is a neuromodulator implicated in nervous system development and plasticity and its effects are mediated by inhibitory (A(1), A(3)) and excitatory (A(2a), A(2b)) receptors. The role of adenosine in the synaptic activity depends mainly on a balanced activation of A(1) and A(2a) receptors which are activated by various ranges of adenosine concentrations. Herein, we investigated the expression of A(1) and A(2a) receptors and also the accumulation of cAMP in the superior colliculus at… CONTINUE READING
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