Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2.

@article{Kunzelmann2005PurinergicIO,
  title={Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2.},
  author={Karl Kunzelmann and Tanja Bachhuber and Ralf R Regeer and Daniel Markovich and Jane S. Sun and Rainer Schreiber},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 1},
  pages={142-3}
}
Stimulation of purinergic receptors inhibits amiloride-sensitive Na+ transport in epithelial tissues by an unknown mechanism. Because previous studies excluded the role of intracellular Ca2+ or protein kinase C, we examined whether purinergic regulation of Na+ absorption occurs via hydrolysis of phospholipid such as phosphatidylinositol-bisphosphates (PIP2). Inhibition of amiloride-sensitive short-circuit currents (Isc-Amil) by adenine 5'-triphosphate (ATP) in native tracheal epithelia and M1… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS