Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter.

  title={Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter.},
  author={Tatyana A Brindikova and Nathalie Bourcier and Brian Torres and Dimitri Pchejetski and Michel Gekle and Georgy V. Maximov and Val{\'e}rie Montminy and Paul A. Insel and Sergei N. Orlov and Paul Isenring},
  journal={American journal of physiology. Cell physiology},
  volume={285 6},
Purinergic inhibition of Na-K-Cl cotransport has been noted in various renal epithelial cells derived from the collecting tubule, including Madin-Darby canine kidney (MDCK) cells. In recent studies, we have observed purinergic inhibition of Na-K-Cl cotransport in C11-MDCK subclones (alpha-intercalated-like cells). Interestingly, Na-K-Cl cotransport activity was also detected in C7-MDCK subclones (principal-like cells) but was not affected by ATP. In this investigation, we have transfected the… CONTINUE READING


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