Purinergic and cholinergic agonists induce exocytosis from the same granule pool in HT29-Cl.16E monolayers.

@article{Bertrand1999PurinergicAC,
  title={Purinergic and cholinergic agonists induce exocytosis from the same granule pool in HT29-Cl.16E monolayers.},
  author={Carol A. Bertrand and Christian L. Laboisse and Ulrich Hopfer},
  journal={American journal of physiology. Cell physiology},
  year={1999},
  volume={276 4},
  pages={C907-C914}
}
Several secretagogues induce mucin secretion in epithelial monolayers, as determined by measuring released granule contents. To assess whether different agonists act on the same granule pool, capacitance changes in intact monolayers of the goblet cell line HT29-Cl.16E were measured by a novel impedance method. Apical ATP (purinergic agonist) and basolateral carbachol (cholinergic agonist) induce rapid exocytosis with maximal capacitance changes within 3 min. The maximal levels of exocytosis… CONTINUE READING

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