Purinergic (P2X7) Receptor Activation of Microglia Induces Cell Death via an Interleukin-1-Independent Mechanism

@article{Brough2002PurinergicR,
  title={Purinergic (P2X7) Receptor Activation of Microglia Induces Cell Death via an Interleukin-1-Independent Mechanism},
  author={David Brough and Rosalind A. Le Feuvre and Yoichiro Iwakura and Nancy J. Rothwell},
  journal={Molecular and Cellular Neuroscience},
  year={2002},
  volume={19},
  pages={272-280}
}
Activation of purinergic P2X7 receptors, principally by extracellular ATP, promotes the processing and release of the cytokine interleukin-1beta (IL-1beta) and induces cell death in activated microglia and macrophages. The objective of this study was to determine if IL-1beta release contributes directly to this cell death in microglia. Exposure of microglia to bacterial lipopolysaccharide (LPS) and ATP induced release of IL-1beta and IL-1alpha, as well as cell death. Neither cell death nor IL-1… CONTINUE READING

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