Purine-rich foods, dairy and protein intake, and the risk of gout in men.

@article{Choi2004PurinerichFD,
  title={Purine-rich foods, dairy and protein intake, and the risk of gout in men.},
  author={Hyon K. Choi and Karen M. Atkinson and Elizabeth W. Karlson and Walter C. Willett and Gary C Curhan},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 11},
  pages={
          1093-103
        }
}
BACKGROUND Various purine-rich foods and high protein intake have long been thought to be risk factors for gout. [] Key Method We used a supplementary questionnaire to ascertain whether participants met the American College of Rheumatology survey criteria for gout. Diet was assessed every four years by means of a food-frequency questionnaire. RESULTS During the 12 years of the study, we documented 730 confirmed new cases of gout.

Tables from this paper

Intake of Purine-rich Foods, Total Meat, Seafood and Dairy Products and Relationship to Serum of Uric Acid
TLDR
The findings of this study suggest that higher amounts of meat and seafood consumption is associated with an increased risk of gout, whereas a higher level of dairy products consumption is inversely associated with a increased risk.
Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men's Health Study.
Diet and gout – what is the role of purines?
TLDR
Evidence indicates that foods which should be avoided or consumed infrequently by gout sufferers are offal, seafood and alcohol, especially beer, whereas dairy foods seem to be protective.
Coffee consumption and risk of incident gout in men: a prospective study.
TLDR
Long-term coffee consumption is associated with a lower risk of incident gout, and total caffeine from all sources and tea intake were not associated with the risk of gout.
Vitamin C intake and the risk of gout in men: a prospective study.
TLDR
Higher vitamin C intake is independently associated with a lower risk of gout, and supplemental vitamin C Intake may be beneficial in the prevention of gouts.
The Association of Dietary Intake of Purine-Rich Vegetables, Sugar-Sweetened Beverages and Dairy with Plasma Urate, in a Cross-Sectional Study
TLDR
The results suggest that limiting purine-rich vegetables intake for lowering plasma urate may be ineffectual, despite current recommendations, and should be reflected in dietary guidelines for hyperuricemic individuals and gout patients.
Gout: epidemiology and lifestyle choices
TLDR
The public health implications of dietary and lifestyle recommendations should take into account other associated health benefits and risks, because many of these factors have health effects beyond their influence on gout.
[Nutritional therapy of gout].
TLDR
The treatment of gout is multi-faceted, since this patient population presents other comorbidities such as obesity, diabetes mellitus, dyslipidemia and hypertension, which require a treatment strategy that is centered on modifying one's nutrition and nutritional behaviours.
Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey.
TLDR
Findings from a nationally representative sample of adults in the US suggest that higher levels of meat and seafood consumption are associated with higher serum levels of uric acid but that total protein intake is not.
Fructose-rich beverages and risk of gout in women.
TLDR
Consumption of fructose-rich beverages is associated with an increased risk of incident gout, although the contribution of these beverages to the risk of gout in the population is likely modest given the low incidence rate among women.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
A controlled study of diet in patients with gout.
TLDR
Though the effect of ingested purine on the blood uric acid is difficult to estimate, it probably was sufficient to have a clinical effect, augmenting the hyperuricaemic effect of alcohol itself.
The influence of dairy products on plasma uric acid in women
TLDR
The study results suggest that proteins of dairy origin may play a role in stabilising or lowering plasma uric acid, and that calcium or other components found in milk products may also reduce diastolic blood pressure.
The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994.
  • H. Kramer, G. Curhan
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 2002
TLDR
Showing an independent association between kidney stone disease and gout strongly suggests that they share common underlying pathophysiological mechanisms, which may lead to improved preventive strategies for both conditions.
Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study
TLDR
It is suggested that weight reduction associated with a change in proportional macronutrient intake, as recently recommended in IR, is beneficial, reducing the SU levels and dyslipidaemia in gout.
Effect of low level lead exposure on hyperuricemia and gout among middle aged and elderly men: the normative aging study.
TLDR
The longterm accumulation of lead is associated with an increased uric acid level in middle aged and elderly men, but this study shows no association between lead and gouty arthritis at the levels arising from community exposure.
Gout, diet, and the insulin resistance syndrome.
  • A. Fam
  • Medicine
    The Journal of rheumatology
  • 2002
TLDR
Although gout is one of the better understood of the rheumatic diseases, and certainly one the most gratifying to treat, a number of management issues, including the role of dietary measures, remain uncertain.
Gout and hyperuricemia.
  • R. Roubenoff
  • Medicine
    Rheumatic diseases clinics of North America
  • 1990
TLDR
Evidence from the Framingham Study suggests that patients with gout should be screened for modifiable risk factors for CHD, and that early intervention in such patients may be worthwhile.
Fish and omega-3 fatty acid intake and risk of coronary heart disease in women.
TLDR
Among women, higher consumption of fish and omega-3 fatty acids is associated with a lower risk of CHD, particularly CHD deaths, particularly for nonfatal myocardial infarction.
Dietary protein and risk of ischemic heart disease in women.
TLDR
The findings suggest that replacing carbohydrates with protein may be associated with a lower risk of ischemic heart disease, because a high dietary protein intake is often accompanied by increases in saturated fat and cholesterol intakes.
...
...