Purine receptors and kynurenic acid modulate the somatosensory evoked potential in rat cerebral cortex.

Abstract

Adenosine and analogues, and antagonists to adenosine and putative excitatory amino acid transmitters were topically applied to the cerebral cortex of urethane-anaesthetised rats and their effects on the somatosensory evoked potentials (SEPs) examined. 2-Chloro-adenosine decreased the amplitude of the SEPs whereas adenosine did not. Both L-(-)N6-phenyl-isopropyladenosine (L-PIA) and 5'-N-ethylcarboxamide adenosine (NECA) depressed the SEPs; the effect of L-PIA was more marked than that of NECA. 8-p-Sulphophenyl theophylline increased the amplitude of the SEPs and also inhibited the effects of 2-chloro-adenosine and L-PIA. Kynurenic acid decreased the amplitude of the SEPs. The results suggest that the initial component of the SEP is a post-synaptic event and that endogenous adenosine probably modulates thalamo-cortical synaptic transmission.

Cite this paper

@article{Addae1988PurineRA, title={Purine receptors and kynurenic acid modulate the somatosensory evoked potential in rat cerebral cortex.}, author={Jonas Innies Addae and Trevor W Stone}, journal={Electroencephalography and clinical neurophysiology}, year={1988}, volume={69 2}, pages={186-9} }