Purine nucleoside transport and metabolism in isolated rat jejunum.

@article{Stow1993PurineNT,
  title={Purine nucleoside transport and metabolism in isolated rat jejunum.},
  author={Rachael Stow and John R Bronk},
  journal={The Journal of physiology},
  year={1993},
  volume={468},
  pages={311-24}
}
1. The absorption and metabolism of purine nucleosides and their constituent bases has been investigated by perfusion through the lumen of isolated loops of rat jejunum. In control perfusions and those with luminal purines or purine nucleosides, high-performance liquid chromatography (HPLC) revealed uric acid as the only detectable purine in the mucosal epithelial layer and the serosal secretions unless the xanthine oxidase inhibitor allopurinol was present. 2. Adenosine (0.5 mM) was… CONTINUE READING