Purine nucleoside phosphorylases: properties, functions, and clinical aspects.

@article{Bzowska2000PurineNP,
  title={Purine nucleoside phosphorylases: properties, functions, and clinical aspects.},
  author={Agnieszka Bzowska and Ewa Kulikowska and David Shugar},
  journal={Pharmacology & therapeutics},
  year={2000},
  volume={88 3},
  pages={349-425}
}
The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function. This review updates the properties of the enzymes from eukaryotes and a wide range of prokaryotes, including a tentative classification of the enzymes from various sources, based on three-dimensional structures in the solid state, subunit composition, amino acid sequences… CONTINUE READING
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