Corpus ID: 2064591

Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds.

@article{Bennett1993PurineNP,
  title={Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds.},
  author={L. Bennett and P. Allan and P. Noker and L. Rose and S. Niwas and J. Montgomery and M. Erion},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={266 2},
  pages={
          707-14
        }
}
  • L. Bennett, P. Allan, +4 authors M. Erion
  • Published 1993
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Certain derivatives of 9-deazaguanine that contain arylmethyl, heteroarylmethyl or cycloalkylmethyl groups at the 9-position are potent inhibitors of purine nucleoside phosphorylase (PNP, E.C. 2.4.2.1). To determine whether these agents can produce metabolically significant inhibition of PNP in cells and in animals, the authors performed pharmacological studies with a representative member of the series, 9-benzyl-9-deazaguanine (BzDAG). BzDAG was a potent inhibitor of PNP from calf spleen (Ki… Expand
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