Purine nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation.

@article{Tomaselli2005PurineNP,
  title={Purine nucleoside-mediated protection of chemical hypoxia-induced neuronal injuries involves p42/44 MAPK activation.},
  author={Bettina Tomaselli and Valerie Podhraski and Veronika Heftberger and Guenther Boeck and Gabriele Baier-Bitterlich},
  journal={Neurochemistry international},
  year={2005},
  volume={46 7},
  pages={513-21}
}
Hypoxia in brain may lead to cell death by apoptosis and necrosis. Concomitant is the formation of purine nucleosides, e.g. adenosine, a powerful endogenous neuroprotectant. Despite vigorous studies, many aspects of the mechanisms involved in purine-based protection are still unclear. In this study, we wanted to investigate the effect of purine nucleosides on cellular responses to chemical hypoxia. O(2)-sensitive neuronal pheochromocytoma (PC12)-cells, which are widely used as a model system… CONTINUE READING