Purine enzyme profile in human colon-carcinoma cell lines and differential sensitivity to deoxycoformycin and 2'-deoxyadenosine in combination.

@article{Camici1995PurineEP,
  title={Purine enzyme profile in human colon-carcinoma cell lines and differential sensitivity to deoxycoformycin and 2'-deoxyadenosine in combination.},
  author={Marcella Camici and Maura Turriani and Maria Grazia Tozzi and Gino Turchi and Joan Cos and Cristina Alemany and Antonio Miralles and V{\'e}ronique No{\'e} and Carlos Ciudad},
  journal={International journal of cancer},
  year={1995},
  volume={62 2},
  pages={176-83}
}
Different cell lines, 2 from human colon carcinoma (LoVo and HT29) and 1 from Chinese hamster ovary (CHO K-I), were examined to assess the effect of deoxycoformycin (dCF), an inhibitor of adenosine deaminase (ADA), and 2'-deoxyadenosine (dAdo) on their growth. When used alone, neither dCF or dAdo were cytotoxic for the 3 cell lines, while their combination caused inhibition of cell growth, with the following sensitivity: CHO K-I > LoVo > HT29. We studied the pattern of enzymatic activities… CONTINUE READING