Purine-crosslinked injectable chitosan sponges promote oligodendrocyte progenitor cells' attachment and differentiation.

@article{Mekhail2015PurinecrosslinkedIC,
  title={Purine-crosslinked injectable chitosan sponges promote oligodendrocyte progenitor cells' attachment and differentiation.},
  author={Mina Mekhail and Guillermina Almazan and Maryam Tabrizian},
  journal={Biomaterials science},
  year={2015},
  volume={3 2},
  pages={
          279-87
        }
}
Oligodendrocyte Progenitor Cells (OPCs) reside in the central nervous system (CNS) and are responsible for remyelinating axons after a spinal cord injury (SCI). However, the remyelination process is incomplete and abnormal due to the inability of OPCs to fully differentiate at the site of injury. In this study a newly developed injectable chitosan sponge crosslinked using guanosine 5'-diphosphate (GDP) was used to enhance OPC survival, attachment and differentiation. This purine-based… CONTINUE READING
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