Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.

@article{Konevega2004PurineBA,
  title={Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.},
  author={Andrey L. Konevega and Natalia G Soboleva and V. I. Makhno and Y. P. Semenkov and Wolfgang Wintermeyer and Marina V. Rodnina and Vladimir I. Katunin},
  journal={RNA},
  year={2004},
  volume={10 1},
  pages={90-101}
}
The anticodon loop of tRNA contains a number of conserved or semiconserved nucleotides. In most tRNAs, a highly modified purine is found at position 37 immediately 3' to the anticodon. Here, we examined the role of the base at position 37 for tRNA(Phe) binding to the A site of Escherichia coli ribosomes. Affinities and rate constants of A-site binding of native yeast peptidyl-tRNA(Phe) with hypermodified G (wybutine), or of unmodified peptidyl-tRNA(Phe) transcripts with G, A, C, or U, at… CONTINUE READING

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